Preclinical Research Services: In Vivo Services


PRESCOS' pharmacology service portfolio is centered around our client needs and focuses on conducting the in life and ex vivo/in vitro portions of rodent (mouse and rat) animal studies. Established services and animal disease models are listed below, please do not hesitate to contact us with your specific needs.

    Pharmacokinetic Studies in Rodents
  • Dose Finding Studies (including MTD determination)
  • Determination of PK parameters for po, iv and ip administration, single and repeat dose
    • Cancer Models
  • Tumor Xenografts: Treatment of human tumors in immuno-compromised mice
  • Syngeneic tumors in immuno-competent mice
    • Autoimmunity Disease Models
      Systemic Lupus Erythematosus (SLE)
  • Spontaneous disease models in mice
  • MRL/MpJ-Faslpr/J mouse model
  • NZBW F1/J mouse model
    • Rheumatoid Arthritis
  • Collagen-Induced Arthritis (CIA) in mouse and rat
  • Collagen Antibody Induced Arthritis (CAIA) in the mouse
  • Streptococcal cell wall induced arthritis in the rat
    • Multiple Sclerosis
  • PLP-induced EAE in SJL/J mice
  • MOG-induced EAE in C57BL/6 mice
  • MBP-induced EAE in Lewis rats
    • Uveitis
  • Mouse (C57BL/6) and rat (Lewis) uveitis using interphotoreceptor retinoid binding protein (IRBP) derived peptides for disease induction
    • Diabetes
  • Streptozotocin-induced diabetes in mice and rats
  • Diabetes in NOD mice
    • Pulmonary Fibrosis
  • Bleomycin-induced pulmonary fibrosis in mice
    • Inflammation Models
  • Bacterial antigen induced inflammatory responses in mice and rats
  • Irritant-induced contact hypersensitivity (CHS) and delayed-type hypersensitivity (DTH) inflammation models
  • Mouse airpouch model (leukocyte migration)
    • Asthma
  • Mouse ovalbumin-induced airway hyperreactivity model (AHR)
    • Inflammatory Bowel Disease (IBD)
  • Dextran Sulfate (DSS) induced gastrointestinal inflammation
  • Oxazolone and Trinitrobenzene Sulfonic Acid (TNBS) induced colitis
    • Vaccine Models
  • Tumor antigens
  • Viral antigens
  • Bacterial antigens

  • We will establish additional rodent animal disease models and other services on the basis of your needs, please contact us with any questions or to discuss your specific projects.


    PRESCOS, in conjunction with its in vivo studies provides diagnostic and analytical services for its clients. Ex vivo and in vitro services and analyses offered at PRESCOS include:

  • Blood, serum and plasma collection and processing
  • Tissue and organ collection and processing
  • Cerebrospinal fluid (CSF) collection and processing
  • Gene expression analyses
  • Serological and immunological assays
  • Cellular assays
  • Histopathology and Immunohistochemistry

  • Please contact us for details concerning your special needs.